![](data:image/svg+xml,<svg display="block" role="presentation" viewBox="0 0 174 36" xmlns="http://www.w3.org/2000/svg"><path d="M 32.455 26.308 C 31.204 28.543 28.367 29.344 26.131 28.093 C 25.858 27.94 25.6 27.76 25.366 27.557 C 25.32 27.518 25.271 27.484 25.22 27.456 C 24.96 27.311 24.641 27.303 24.371 27.447 C 24.049 27.619 23.865 27.971 23.908 28.334 C 24.083 29.781 23.799 31.22 23.085 32.493 C 21.238 35.793 17.05 36.974 13.75 35.127 C 12.597 34.482 11.662 33.525 11.045 32.361 C 10.444 31.226 10.172 29.95 10.258 28.671 C 10.281 28.33 10.104 28.007 9.807 27.84 C 9.797 27.835 9.787 27.829 9.777 27.824 C 9.462 27.663 9.081 27.705 8.809 27.931 C 8.094 28.525 7.224 28.889 6.293 28.982 C 5.343 29.079 4.4 28.882 3.565 28.415 C 1.33 27.165 0.529 24.329 1.78 22.094 C 2.325 21.12 3.204 20.376 4.256 19.997 C 4.6 19.872 4.833 19.548 4.84 19.182 C 4.846 18.853 4.67 18.551 4.388 18.393 C 4.355 18.375 4.322 18.358 4.287 18.344 C 4.022 18.237 3.76 18.111 3.508 17.97 C 0.207 16.123 -0.975 11.937 0.873 8.638 C 2.72 5.339 6.908 4.156 10.209 6.003 C 10.46 6.144 10.705 6.302 10.935 6.472 C 10.966 6.494 10.997 6.514 11.029 6.532 C 11.311 6.69 11.661 6.683 11.938 6.505 C 12.247 6.308 12.402 5.94 12.328 5.581 C 12.101 4.487 12.276 3.349 12.821 2.375 C 14.073 0.14 16.91 -0.66 19.145 0.591 C 19.98 1.058 20.641 1.759 21.056 2.618 C 21.462 3.46 21.607 4.391 21.475 5.311 C 21.424 5.661 21.588 6.008 21.89 6.192 C 21.899 6.198 21.909 6.204 21.919 6.209 C 22.216 6.375 22.584 6.356 22.863 6.158 C 23.908 5.416 25.138 4.982 26.421 4.9 C 27.737 4.817 29.041 5.114 30.194 5.759 C 33.495 7.605 34.677 11.792 32.829 15.091 C 32.116 16.364 31.039 17.359 29.713 17.967 C 29.381 18.119 29.176 18.46 29.198 18.824 C 29.217 19.129 29.39 19.398 29.65 19.543 C 29.701 19.572 29.755 19.595 29.813 19.614 C 30.108 19.708 30.397 19.834 30.67 19.986 C 32.905 21.237 33.706 24.074 32.455 26.308 Z M 21.972 11.014 C 21.077 12.613 21.647 14.634 23.247 15.529 C 24.847 16.424 26.869 15.854 27.765 14.255 C 28.66 12.656 28.089 10.634 26.489 9.739 C 24.89 8.844 22.867 9.415 21.972 11.014 Z M 15.143 5.003 C 14.606 5.963 14.948 7.176 15.908 7.713 C 16.868 8.25 18.082 7.907 18.619 6.948 C 19.156 5.988 18.813 4.775 17.854 4.239 C 16.894 3.701 15.681 4.044 15.143 5.003 Z M 7.1 16.076 C 8.699 16.971 10.722 16.4 11.617 14.801 C 12.513 13.202 11.942 11.18 10.342 10.285 C 8.743 9.391 6.72 9.961 5.825 11.56 C 4.929 13.159 5.5 15.181 7.1 16.076 Z M 8.691 24.655 C 9.228 23.696 8.885 22.482 7.926 21.945 C 6.966 21.409 5.753 21.751 5.215 22.71 C 4.678 23.669 5.021 24.883 5.981 25.42 C 6.94 25.957 8.154 25.614 8.691 24.655 Z M 20.045 28.583 C 20.941 26.984 20.37 24.962 18.77 24.067 C 17.17 23.172 15.148 23.743 14.253 25.342 C 13.357 26.941 13.928 28.963 15.528 29.858 C 17.127 30.753 19.15 30.182 20.045 28.583 Z M 24.346 21.771 C 24.725 21.094 25.271 20.519 25.927 20.109 C 26.237 19.915 26.395 19.551 26.326 19.192 C 26.276 18.931 26.113 18.712 25.889 18.587 C 25.805 18.54 25.713 18.506 25.615 18.488 C 24.872 18.354 24.158 18.097 23.494 17.725 C 22.131 16.963 21.062 15.745 20.481 14.295 C 19.909 12.865 19.832 11.27 20.263 9.806 C 20.363 9.466 20.251 9.099 19.979 8.874 C 19.937 8.84 19.893 8.809 19.847 8.784 C 19.591 8.64 19.277 8.632 19.009 8.769 C 17.617 9.485 15.972 9.46 14.611 8.7 C 14.291 8.521 13.893 8.558 13.612 8.793 C 13.33 9.028 13.223 9.412 13.343 9.759 C 13.977 11.606 13.795 13.639 12.844 15.336 C 11.894 17.033 10.255 18.251 8.349 18.677 C 7.991 18.756 7.72 19.049 7.666 19.411 C 7.613 19.774 7.789 20.132 8.109 20.312 C 9.469 21.074 10.351 22.462 10.468 24.023 C 10.491 24.323 10.662 24.586 10.918 24.729 C 10.964 24.755 11.014 24.777 11.064 24.794 C 11.399 24.909 11.771 24.813 12.008 24.55 C 13.031 23.416 14.431 22.648 15.95 22.388 C 17.49 22.124 19.088 22.399 20.451 23.161 C 21.115 23.533 21.707 24.007 22.211 24.569 C 22.277 24.644 22.354 24.705 22.438 24.751 C 22.661 24.876 22.934 24.901 23.183 24.807 C 23.524 24.679 23.752 24.353 23.756 23.988 C 23.762 23.215 23.967 22.449 24.347 21.771 Z M 29.008 24.38 C 29.545 23.421 29.202 22.207 28.243 21.67 C 27.283 21.133 26.069 21.476 25.532 22.435 C 24.995 23.395 25.337 24.608 26.297 25.145 C 27.257 25.682 28.47 25.34 29.008 24.38 Z" fill="rgb(10, 15, 26)" height="35.99998404676664px" id="L9i9lfmGB" transform="translate(0 0)" width="33.70212491897429px"/><path d="M 5.764 19.383 L 0 0 L 2.734 0 L 6.273 11.849 C 6.541 12.868 6.809 13.887 7.077 15.361 C 7.399 13.806 7.694 12.868 7.989 11.849 L 11.662 0 L 14.503 0 L 18.149 11.849 C 18.471 12.895 18.739 13.914 19.034 15.361 C 19.356 13.726 19.624 12.734 19.892 11.876 L 23.457 0 L 26.138 0 L 20.294 19.383 L 17.774 19.383 L 13.083 4.048 L 8.337 19.383 Z" fill="rgb(10, 15, 26)" height="19.382559999999998px" id="iCH2wvtmH" transform="translate(42.701 8.322)" width="26.1383px"/><path d="M 6.568 11.501 L 0 0 L 2.949 0 L 7.265 7.748 C 7.533 8.203 7.694 8.579 7.909 9.034 C 8.15 8.552 8.203 8.391 8.552 7.748 L 12.841 0 L 15.71 0 L 9.195 11.501 L 9.195 19.383 L 6.568 19.383 Z" fill="rgb(10, 15, 26)" height="19.382559999999998px" id="l1jcMQyEW" transform="translate(68.702 8.322)" width="15.709800000000001px"/><path d="M 2.627 19.383 L 0 19.383 L 0 0 L 2.627 0 L 12.546 14.986 L 12.546 0 L 15.173 0 L 15.173 19.383 L 12.546 19.383 L 2.627 4.397 Z" fill="rgb(10, 15, 26)" height="19.382559999999998px" id="PuuQLPXs7" transform="translate(86.14 8.322)" width="15.173200000000008px"/><path d="M 7.373 19.383 L 0 0 L 2.815 0 L 7.533 12.386 C 7.962 13.485 8.338 14.584 8.74 16.031 C 9.195 14.503 9.651 13.217 9.973 12.359 L 14.664 0 L 17.399 0 L 10.107 19.383 Z" fill="rgb(10, 15, 26)" height="19.382559999999998px" id="LZpnHzXku" transform="translate(103.039 8.322)" width="17.399px"/><path d="M 11.823 19.383 L 0 19.383 L 0 0 L 11.823 0 L 11.823 2.413 L 2.627 2.413 L 2.627 8.471 L 10.911 8.471 L 10.911 10.804 L 2.627 10.804 L 2.627 16.943 L 11.823 16.943 Z" fill="rgb(10, 15, 26)" height="19.382559999999998px" id="PY7hKwFi7" transform="translate(122.152 8.322)" width="11.822999999999993px"/><path d="M 2.628 19.383 L 0 19.383 L 0 0 L 7.319 0 C 11.475 0 13.941 2.198 13.941 5.817 C 13.941 8.498 12.6 10.429 10.188 11.206 L 14.129 19.383 L 11.206 19.383 L 7.587 11.715 L 2.628 11.715 Z M 2.628 2.359 L 2.628 9.383 L 7.346 9.383 C 9.786 9.383 11.18 8.069 11.18 5.844 C 11.18 3.592 9.732 2.359 7.319 2.359 Z" fill="rgb(10, 15, 26)" height="19.382559999999998px" id="CI8cAX3SV" transform="translate(136.977 8.322)" width="14.12899999999999px"/><path d="M 2.627 0 L 2.627 19.383 L 0 19.383 L 0 0 Z" fill="rgb(10, 15, 26)" height="19.382559999999998px" id="iTXkSnT3f" transform="translate(153.714 8.322)" width="2.6270000000000095px"/><path d="M 0.268 5.576 C 0.268 2.252 2.949 0 6.943 0 C 10.643 0 13.029 2.064 13.243 5.415 L 10.589 5.415 C 10.455 3.485 9.088 2.359 6.916 2.359 C 4.477 2.359 2.895 3.592 2.895 5.496 C 2.895 7.051 3.78 7.989 5.603 8.418 L 8.793 9.168 C 11.956 9.892 13.565 11.608 13.565 14.343 C 13.565 17.828 10.857 20.053 6.729 20.053 C 2.788 20.053 0.161 17.988 0 14.664 L 2.681 14.664 C 2.734 16.514 4.289 17.694 6.729 17.694 C 9.302 17.694 10.938 16.487 10.938 14.557 C 10.938 13.029 10.107 12.064 8.257 11.635 L 5.067 10.911 C 1.903 10.187 0.268 8.364 0.268 5.576 Z" fill="rgb(10, 15, 26)" height="20.05277px" id="Hkn9knIuz" transform="translate(158.663 7.974)" width="13.564999999999998px"/></svg>)
Towards Wnt inhibition without prohibitive toxicity
Towards Wnt inhibition without prohibitive toxicity
Wnt fuels cancer growth and drug resistance in millions of patients each year - yet any attempts to drug it have been blocked by toxicity.
Wnt fuels cancer growth and drug resistance in millions of patients each year - yet any attempts to drug it have been blocked by toxicity.
The Unmet Need
Wnt drives cancer drug resistance
For millions of patients annually, Wnt drives cancer growth and drug resistance
Implicated across all major solid tumors
The Unmet Need
Wnt drives cancer drug resistance
For millions of patients annually, Wnt drives cancer growth and drug resistance
Implicated across all major solid tumors
The Problem
Broad Inhibition is overly toxic
No approved Wnt inhibitor drug
Pharma giants tried for 30+ Years
Described as undruggable
The Problem
Broad Inhibition is overly toxic
No approved Wnt inhibitor drug
Pharma giants tried for 30+ Years
Described as undruggable
The Innovation
Receptor Selective Inhibition
Targeting the specific Wnt receptor a tumor relies on for survival and resistance
Healthy tissue can rely on other receptors
The Innovation
Receptor Selective Inhibition
Targeting the specific Wnt receptor a tumor relies on for survival and resistance
Healthy tissue can rely on other receptors
The Opportunity
Engineered For Tolerability
First-in-class Wnt inhibitor molecule with a wide theraupetic window
Mono- and combination therapy potential
The Opportunity
Engineered For Tolerability
First-in-class Wnt inhibitor molecule with a wide theraupetic window
Mono- and combination therapy potential
Explore our preclinical data
Explore our
preclinical data
Book a call to meet a founder, learn more about our data, and discuss what selective Wnt inhibition could mean for oncology.
Book a call to meet a founder, learn more about our data, and discuss what selective Wnt inhibition could mean for oncology.
Phase 2
Phase 2
Phase 1
Phase 1
Pre-Clinical
Pre-Clinical
Research
Research
The Team
The Team
Pioneered by scientists with two decades and 8,000+ citations in Wnt research. Backed by business veterans.
Pioneered by scientists with two decades and 8,000+ citations in Wnt research. Backed by business veterans.
